Cell Culture Media, Supplements, and Reagents
![Medchemexpress LLC Methyl N-[[(5S)-3-[3-fluoro-4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl... | 2071265-08-0 | 99.7% | C17H20FN3O5 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261284.png-250.jpg)
Medchemexpress LLC Methyl N-[[(5S)-3-[3-fluoro-4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl... | 2071265-08-0 | 99.7% | C17H20FN3O5 | 10MG
TBI-223 is an orally active oxazolidinone-class antibiotic research compound showing activity against Mycobacterium tuberculosis and demonstrated efficacy in mouse infection models. It inhibits mitochondrial protein synthesis in HepG2 cells and is supplied as a solid with defined storage recommendations for long-term stability.
- Orally active oxazolidinone scaffold.
- Shows activity against Mycobacterium tuberculosis.
- Demonstrated efficacy in multiple mouse infection models.
- Inhibits mitochondrial protein synthesis in HepG2 cells (IC50 = 68 μg/mL).
- High purity and defined storage conditions for stability.
eMolecules Medchem Express / AZD-8835 / 5mg / 446261997 / HY-12869 / / 1620576-64-8 / MFCD28902194 / 469.550 / C22H31N9O3
Medchem Express / AZD-8835 / 5mg / 446261997 / HY-12869 / / 1620576-64-8 / MFCD28902194 / 469.550 / C22H31N9O3
eMolecules Medchem Express / Acumapimod / 5mg / 446267746 / HY-16715 / / 836683-15-9 / MFCD28902244 / 385.427 / C22H19N5O2
Medchem Express / Acumapimod / 5mg / 446267746 / HY-16715 / / 836683-15-9 / MFCD28902244 / 385.427 / C22H19N5O2
Medchemexpress LLC Ribostamycin sulfate | 53797-35-6 | 99.55% | 100 MG
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial that inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding. It also inhibits the chaperone activity of protein disulfide isomerase (PDI). It is used in pharmacokinetic and nephrotoxicity studies.
- Broad-spectrum antimicrobial activity.
- Inhibits bacterial protein synthesis at 30S and 50S ribosomal subunits.
- Inhibits the chaperone activity of protein disulfide isomerase (PDI).
- Effective against both gram-positive and gram-negative cocci and bacilli, including drug-resistant strains.
- Especially effective against gentamicin-resistant *Klebsiella pneumoniae*.
- Available for research use only.
Medchemexpress LLC Tomatidine hydrochloride | 6192-62-7 | 50 MG
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It also activates autophagy in mammal cells or C elegans. In vitro, Tomatidine decreases inducible NO synthase and COX-2 expression by suppressing I-κBα phosphorylation, NF-κB nuclear translocation, and JNK activation, which subsequently inhibits c-jun phosphorylation and Oct-2 expression. It causes dose-dependent inhibition of LPS-induced iNOS expression and suppresses the binding activity of NF-κB.
- Acts as an anti-inflammatory agent
- Blocks NF-κB and JNK signaling pathways
- Activates autophagy in mammal cells or C elegans
- Decreases inducible NO synthase and COX-2 expression
- Inhibits I-κBα phosphorylation and NF-κB nuclear translocation
- Suppresses JNK activation and c-jun phosphorylation
- Inhibits LPS-induced iNOS expression
- Suppresses NF-κB binding activity
Medchemexpress LLC GO-203 TFA | 1222186-26-6 | 98.39% | 2426.77 | 5 MG
GO-203 TFA is a potent inhibitor of the MUC1-C oncoprotein. It is an all D-amino acid peptide that contains a poly-R transduction domain linked to a CQCRRKN motif, which binds to the MUC1-C cytoplasmic tail and prevents MUC1-C homodimerization. This compound downregulates TIGAR protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. It also induces the production of Reactive Oxygen Species (ROS) and leads to a loss of mitochondrial transmembrane potential. GO-203 TFA has been shown to inhibit the growth of colon cancer cells both in vitro and as xenografts in nude mice.
- Potent MUC1-C oncoprotein inhibitor
- All D-amino acid peptide
- Blocks MUC1-C homodimerization
- Downregulates TIGAR protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway
- Induces ROS production and loss of mitochondrial transmembrane potential
- Inhibits the growth of colon cancer cells in vitro and in xenografts in nude mice
Medchemexpress LLC Sri-011381 | 1629138-41-5 | MFCD01475985 | 99.6% | 329.48 g/mol | C20H31N3O | 50 MG
SRI-011381 is a small-molecule agonist of the TGF-β/Smad signaling pathway with reported neuroprotective effects. It is provided as a research-use chemical in powder and solution formats for in vitro and in vivo studies.
- Orally active TGF-β/Smad signaling agonist
- Reported neuroprotective effects in preclinical studies
- Molecular formula C20H31N3O; molecular weight 329.48 g/mol
- CAS number 1629138-41-5
- High purity (~99.6%)
- Available as dry powder and as 10 mM solution in DMSO
- Store at 4°C protected from light; in solvent store at -80°C (6 months) or -20°C (1 month)
Apexbio Technology LLC Sulfadoxine 2447-57-6 5g
Sulfadoxine (CAS 2447-57-6) is a small-molecule inhibitor targeting dihydropteroate synthase It is designed to competitively inhibit this enzyme thereby disrupting folate biosynthesis in Plasmodium parasites Sulfadoxine exerts its biological activity primarily through inhibition of dihydropteroate synthase mediated folate synthesis In cell-based studies sulfadoxine demonstrates inhibitory activity against human immunodeficiency virus (HIV) replication within peripheral blood mononuclear cells (PBMCs) with an IC50 value in the micromolar range Based on these pharmacological properties sulfadoxine holds research potential in antimalarial drug investigation parasite metabolic pathway studies pathogen susceptibility assays antiviral pharmacological experiments and investigations of host-pathogen interactions and viral replication mechanisms
Sigma Aldrich Fine Chemicals Biosciences (-)-Epothilone B from Sorangium cellulosum, >=98% (HPLC) | 152044-54-7 | MFCD02101921 | 1MG
(-)-Epothilone B from Sorangium cellulosum, >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 507.68 | 152044-54-7 | MFCD02101921 | 1MG
Medchemexpress LLC Cl-amidine (hydrochloride) | 1373232-26-8 | 99.4% | 347.25 g·mol⁻¹ | C14H20Cl2N4O2 | 100 MG
Cl-amidine hydrochloride is the hydrochloride salt of Cl-amidine, a peptidylarginine deiminase (PAD) inhibitor used in biochemical and cellular research. It is supplied as a white to light yellow solid with batch-specific high purity and is applied to inhibit PAD-mediated protein citrullination in vitro and in vivo studies.
- High purity suitable for biochemical and cellular research.
- Pan-PAD inhibition activity for PAD1, PAD3, and PAD4 studies.
- White to light yellow solid for stable storage and handling.
- Molecular weight 347.25 g·mol⁻¹ for accurate dosing.
- Recommended storage at -20°C under nitrogen to preserve stability.
Medchemexpress LLC ILK-IN-3 50mg | 6975-75-3 | 50 MG
ILK-IN-3 is an orally active integrin-linked kinase (ILK) inhibitor supplied as a 50 mg research reagent. It is used in preclinical studies to modulate ILK activity and has been reported to enhance the anticancer efficacy of docetaxel in orthotopic LCC6 models. For research use only.
- Orally active ILK inhibitor suitable for in vitro and in vivo studies.
- Reported to improve docetaxel anticancer efficacy in LCC6 model.
- High purity (>99% by LCMS) for reproducible results.
- Supplied as a solid powder with recommended cold storage for stability.
- Provided with certificate of analysis and datasheet for quality and handling information.
Apexbio Technology LLC Azomycin 527-73-1 250mg
Azomycin (CAS 527-73-1) is a small-molecule inhibitor that interferes with electron transport pathways in aerobic Gram-positive and Gram-negative bacteria It is designed to disrupt cellular electron transfer processes thereby inhibiting bacterial respiratory function Azomycin exerts its biological activity primarily through inhibition of microbial electron transport In in vitro assays Azomycin demonstrates inhibitory activity with IC50 values typically in the micromolar concentration range though specific values may vary depending on bacterial strain and experimental conditions Based on these pharmacological properties Azomycin holds research potential in studies of bacterial metabolic pathways antimicrobial resistance mechanisms and novel antibacterial therapeutic strategies
Medchemexpress LLC Ulipristal | 159811-51-5 | ≥98.0% | 433.58 | 100 MG
Ulipristal is a selective progesterone receptor modulator (SPRM). It functions by binding to the progesterone receptor, which inhibits PR-mediated gene expression and interferes with progesterone activity in the reproductive system.
- May suppress the growth of uterine leiomyomatosis.
- Can be used as an emergency contraception.
- Inhibits or delays ovulation.
- Affects endometrial tissue.
Sigma Aldrich Fine Chemicals Biosciences Toloxatone >=98% (HPLC), solid | 29218-27-7 | MFCD00865391 | 50MG
Toloxatone >=98% (HPLC), solid | Purity: >=98% (HPLC) | Mol Wt: 207.23 | 29218-27-7 | MFCD00865391 | 50MG
Medchemexpress LLC HS-276 | 2767422-72-8 | 98.9% | 419.52 | 100 MG
HS-276 is an orally active, potent, and highly selective TAK1 inhibitor with a Ki of 2.5 nM. It significantly inhibits multiple kinases, including TAK1, CLK2, GCK, ULK2, and MAP4K5. This compound is useful for rheumatoid arthritis (RA) research due to its ability to reduce inflammation and improve arthritis markers in models.
- Orally active and highly selective TAK1 inhibitor
- Inhibits various kinases, such as TAK1, CLK2, and GCK
- Reduces expression of TNF, IL-6, and IL-1β
- Decreases inflammation and cartilage damage in inflammatory arthritis models
- Exhibits excellent bioavailability in in vivo studies
- Suitable for rheumatoid arthritis research